Welcome To Darnatein


Inventing Modular Molecules for Life Design-Augmented RNA and Protein Biotherapeutics

 About Us


We create superagonists to cure patients better than Mother Nature.

 Welcome To Darnatein

Tissue Regeneration Through Design Augmented Therapeutics

Darnatein

Our body’s aging process is bound by a natural set of signals and genes that make up our genetic codes. Our scientific strategy at Darnatein is to restore the balance of the signals between agonists and antagonists in the body. Certain agonist signals, for instance, those that maintain healthy cartilage, decrease naturally as we age. By creating super-agonists involved in tissue regeneration, we can overcome such natural barriers.


 Research Area


Curing Better Than Mother Nature
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Design Augmented + RNA + Protein = Darnatein



At Darnatein, we use a unique synthetic biology approach to cure patients better than Mother Nature. Design-Augmented (DA) RNA and protein biotherapeutics, such as DRT-101 and DRT-102, are being developed at Darnatein to cure age-related disorders in the spine and joint cartilage. Current regimens available to patients with spine and joint cartilage disorders are conducted either by surgery or pain-managing NSAID drugs. DRT-101 provides a new mechanism of action as a potential DMOAD (Disease-Modifying Osteoarthritis Drug).

We integrate different protein domain sequences into a recombinant biologic with enhanced biological functionality. Darnatein's DA-BMPs are engineered for enhanced therapeutic potency, reducing required doses and minimizing adverse events.  Clinical studies for bone fusion showed an excellent safety profile. 



Darnatein


 Our Vision
How we're shaping the world

Learn how Darnatein is striving to transforming healthcare and improve lives


 Our Technology
A unique synthetic biology platform 

Design-Augmented novel protein chimeras with superior efficacy compared to their natural parent ligands


 Pipeline
Curing Better Than Mother Nature
 

 Vision


Health-conscious company

 Pipeline


Advancing medicines that matter

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